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Acidic conditions in the stomach, various hydrolytic enzymes, and bile salts in the gastrointestinal tract also adversely affect the viability of LR after ingestion. Processing conditions during formulation and noncompliance with storage requirements during shipment and storage result in loss of cell viability in the dosage formulation. 1 LR is well tolerated with very rare side effects, and its regular intake can be effective in supplementing and maintaining digestive tract health. Reported therapeutic benefits are associated with the ability of LR to secret coagulin, a bacteriocin, which is active against a broad spectrum of enteric microbes. Intake of viable Lactobacillus rhamnosus ( LR) cells, at around 10 7 cfu, 1, 2 aids in the prevention of intestinal tract illnesses, 3 suppresses bacterial infection in renal patients, 4 safeguards the urogenital tract by excreting biosurfactants, 5 stimulates antibody production, aids the immune system, assists the phagocytic process, helps the body to combat dangerous invasive bacteria, controls food-associated allergic inflammation, 6 shortens the duration of diarrhea associated with rotavirus infection, 7 and reduces use of antibiotics to treat Helicobacter pylori infection.